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In the GHK-Cu complex, the copper ion coordinates with multiple binding sites: the nitrogen from the histidine imidazole side chain, the alpha-amino group of glycine, the deprotonated amide nitrogen of the glycine-histidine peptide bond, and oxygen from the lysine carboxyl group, forming a square-planar pyramid configuration

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In the context of resistance training in elderly subjects with sarcopenia, collagen peptide supplementation in combination with resistance training has been shown to further improve body composition by increasing fat-free mass, muscle strength, and reducing fat mass [6]